Self-assembled carbon monoxide nanogenerators managing sepsis through scavenging multiple inflammatory mediators

Self-assembled carbon monoxide nanogenerators managing sepsis through scavenging multiple inflammatory mediators

Blog Article

Sepsis, a life-threatening syndrome of organ damage resulting from dysregulated inflammatory response, is distinguished by overexpression of inflammatory cytokines, excessive generation of reactive oxygen/nitrogen species (RONS), heightened activation of pyroptosis, and suppression of autophagy.However, current clinical symptomatic supportive treatment Outdoor Round End Table has failed to reduce the high mortality.Herein, we developed self-assembled multifunctional carbon monoxide nanogenerators (Nano CO), as sepsis drug candidates, which can release CO in response to ROS, resulting in clearing bacteria and activating the heme oxygenase-1/CO system.This activation strengthened endogenous protection and scavenged multiple inflammatory mediators to alleviate the cytokine storm, including scavenging Rear-View Camera RONS and cfDNA, inhibiting macrophage activation, blocking pyroptosis and activating autophagy.

Animal experiments show that Nano CO has a good therapeutic effect on mice with LPS-induced sepsis, which is manifested in hypothermia recovery, organ damage repair, and a 50% decrease in mortality rates.Taken together, these results illustrated the efficacy of multifunctional Nano CO to target clearance of multiple mediators in sepsis treatment and act against other refractory inflammation-related diseases.